WHAT IS A CELL

WHAT IS A CELL

Touchaheart Nigeria brings to you information on cells, to help those in need of this information understand its meaning. Read till the end.

Autoimmunity to the islets may lead to β-cell dysfunction in type 2 diabetes (T2D). However, its frequency and clinical relevance have yet to be identified. For a study, researchers assessed the incidence of cellular and humoral islet autoimmunity in individuals with T2D for 4.0±3.0 years (HbA1c 7.5± 0.5% on metformin alone) in auxiliary research to the Glycemia Reduction Approaches in Diabetes: A Comparative Effectiveness Study (GRADE).

T-cell autoreactivity against islet proteins, islet autoantibodies against the 65-kDa GAD antigen, IA-2, and zinc transporter-8, and β-cell function were all assessed. 41.3% had cellular islet autoimmune, 13.5% had humoral islet autoimmunity, and 5.3% had both. β-Cell function (iAUC-CG) and C-peptide(0–30)/glucose(0–30) from an oral glucose tolerance test were lower in T-cell–positive (T+) than T-cell–negative (T) individuals using two different adjustments for insulin sensitivity (iAUC-CG: 13.2% [95% CI 0.3, 24.4] or 11.4% [95% CI 0.4, 21.2] lower; C-peptide[0– T+ patients had a 17% higher HbA1c (95% CI 0.07, 0.28) and 7.7 mg/dL higher fasting plasma glucose levels (95% CI 0.2, 15.3) than T patients.

They concluded that islet autoimmunity was far more common in T2D patients than previously thought. Furthermore, autoimmunity mediated by T cells was linked to decreased β-cell function and poor glycemic management.

Reference:diabetesjournals.org/diabetes/article/71/6/1261/140947/Islet-Autoimmunity-Is-Highly-Prevalent-and